Brian Ingalls
Departments of Applied Mathematics, Biology, and Chemical Engineering, University of Waterloo
Kinetic modelling in systems and synthetic biology
Abstract: The behaviour of intracellular biomolecular networks often defies intuition, especially in the presence of nonlinear interactions and feedback. Dynamic mathematical models provides a foundation for the investigation and design of such systems. This talk will introduce the use of these modelling tools for describing intracellular networks in the context of systems and synthetic biology. An on-going project addressing the characterization and manipulation of bacterial genetics will be used as a case study to illustrate a range of modelling techniques: model development, model comparison, uncertainty analysis and model-based optimal experimental design.
Abstract: The behaviour of intracellular biomolecular networks often defies intuition, especially in the presence of nonlinear interactions and feedback. Dynamic mathematical models provides a foundation for the investigation and design of such systems. This talk will introduce the use of these modelling tools for describing intracellular networks in the context of systems and synthetic biology. An on-going project addressing the characterization and manipulation of bacterial genetics will be used as a case study to illustrate a range of modelling techniques: model development, model comparison, uncertainty analysis and model-based optimal experimental design.
Biography
Brian Ingalls is a faculty member in the Department of Applied Mathematics at the University of Waterloo, where he is cross-appointed to the departments of Biology and Chemical Engineering. His research in systems and synthetic biology is focused on the development of mathematical models to predict the behavior of intracellular molecular networks and heterogeneous cellular communities.
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